I have been using Nexavar for Hepatocellular Carcinoma for nearly a year, I did develop a skin rash but nothing too distressing. I had slight hair loss and thinning but its starting to grow back. I also developed mild colitis but have found Omeprazole helps really well. I also have insomnia but my doctor prescribed sleeping tablets which I use occasionally. Apart from occasional tumor pain I feel great, and I am on the maximum dose. The tumor has shrunk considerably and is now stable, my blood tests are normal.