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Esbriet

Esbriet

Also Known as: Etuary, Pirespa, etc.

Active Ingredients: Pirfenidone (pir FEN i done)

Inactive Ingredients: Croscarmellose sodium, Microcrystalline cellulose, Colloidal anhydrous silica, Macrogol (polyethylene glycol), Povidone magnesium stearate, Polyvinyl alcohol, Iron oxide, Titanium dioxide, and Talc.

Drug Information

Esbriet is sold as a hard, off-white gelatin capsule, having 267 mg of Pirfenidone, andas yellow or brown film-coated tablets having either 267 mg or 801 mg of the active ingredient. The oral medicine is prescribed for treating IPF or Idiopathic Pulmonary Fibrosis. Pirfenidone present in the medication downregulates the synthesis of Procollagens I and II (growth factors) that cause lung fibrosis.

After several clinical trials, the drug was first approved in Japan and sold by Shionogi under the trade name of Pirespa. Later in 2012, the Canadian pharmacists approved and sold it as Esbriet. In October 2014, the FDA finally approved it for IPF treatment in the United States.

Why is it prescribed

IPF is a terrible disease that causes scarring in the lung tissues. The scarred tissues gradually thicken over time, becoming stiff, which ultimately affects the respiratory capacity of our lungs. Diminished lung function causes breathing problems. It may affect our vital functions due to oxygen deprivation in the heart and brain.

Though Esbriet does not completely cure IPF, the medicine slows down the progress of this disease, making it less life-threatening.

How to use Esbriet

The suggested daily dosage of Esbriet is 2403 mg/day split into 3 doses of 801 mg each. Patients should take these oral pills with water at least three times a day, after meals. Your doctors may prescribe a different dose, based on your medical history, drug response and weight.

Ideally, one should start at a low dose and gradually increase one dose per week, until you are comfortable with having the standard dosage.

Taking it with food prevents nausea, dizziness, and other probable side-effects. Always take your pills at the same time every day.

What if I Miss a Dose or Overdose

You may take the missed dose as soon as you remember. Make sure that you maintain a standard time period of 8 hours between 2 consecutive doses. Do not take extra medicine or two doses close together to make up for the missed medicine. In case of a drug overdose, seek immediate medical attention at 911 or the Poison Helpline number 1-800-222-1222.

Esbriet Side Effects

  • Headaches
  • Exhaustion
  • Nausea
  • Fatigue
  • Dizziness
  • Vomiting
  • Weight loss
  • Upset stomach
  • Indigestion
  • Diarrhea
  • Loss of appetite
  • Heartburn
  • Rashes
  • Cold symptoms (like sneezing, sore throat, runny nose)
  • Increased sensitivity to the sunlight
  • Abdominal pain, joint pain
  • Insomnia
  • Sinus infection
  • Infection in the upper respiratory tract

Drug Interactions

Other medicines like rifampin, phenytoin, and drugs that treat mental disorders can interfere with the functioning of Pirfenidone.

Precautions

  • Though Pirfenidone does not cause any potential harm to the fetus, it can penetrate the placenta and seep into breast milk. Avoid taking the drug if you are expecting or breastfeeding a child.
  • Use a sunscreen of SPF 30 or higher when you head outdoors. The drug increases your sensitivity to the sunlight. Hence, you’re likely to get a sunburn.
  • Do not take it with antibiotics.
  • Avoid smoking. Nicotine produces violent drug reactions.

Key Facts

  • Esbriet has been used successfully by over 37,000 patients worldwide.

    • Clinical studies have revealed that IPF patients treated with Esbriet are more likely to have a healthier baseline lung function than those who are not on this drug.

Important

HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

  1. GENERIC

    Drug Name

    Prescription Required

    Salt Name

    Action

  2. GENERIC EQUIVALENT TO ESBRIET 200mg

    Yes

    Pirfenidone

! Important Note: We do not dispense any prescription medicine without valid and legible prescription written by your local Physician. All prescriptions must be presented from a verifiable and licensed physician.

! Important Note: We are only able to ship a maximum 90-day supply of your prescription.

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